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How Thyroid Hormones Affect Mood, Weight, and Energy


Consequently, patients with hypothyroidism are more likely to develop clinical depression due to severely low levels of T3 and T4.

For instance, hypothyroidism patients often complain of experiencing apathy, mood swings, and psychomotor dysfunction.

In a 2019 meta-analysis, linked subclinical hypothyroidism to depression, where it was found that the first could negatively impact the latter.

Moreover, another link between hypothyroidism and low levels of serotonin was established, which is quickly reversed after the administration of synthetic thyroid hormones.

Keep in mind that low serotonin levels in the central nervous system is the primary pathogenesis in people with depression.

If you notice mood swings, then it's prudent to also test the master hormone 's full function in the body – triiodothyronine – a.k.a. active T3. The reason for feeling more depressed, anxious, blue or flat can be even suboptimal thyroid hormones. Therefore, if you ever feel like you’re going through unstable mood fluctuations that cannot be explained by another underlying cause, it might be a good idea to check your thyroid hormones (e.g., T3, T4).

Weight loss and hypothyroidism

Weight loss occurs when your body is in a state of Adenosine triphosphate (ATP) efficacy, as this is the primary carrier of energy in cells, where the cellular machinery is burning more calories than you are consuming.

The primary form of energy that the body uses is glucose, which is utilised to produce adenosine triphosphate (ATP).

The degree of ATP use is strictly controlled by the thyroid hormones, which could explain why some people with subclinical hypothyroidism might be gaining weight despite their attempts to diet and exercise.

To help the body restore its functionality and energy-producing abilities, you need to correct your thyroid hormone balance to alleviate fatigue and induce faster lipolysis (i.e., fat burning).

Therefore, instead of opting for caffeine or other stimulants even prescription drugs to promote your energy and induce fat loss, it is vital to correct the aetiology of this issue – hypothyroidism – first.

Sadly, however, most available tests do not detect mild hypothyroidism, which is enough to cause a wide range of symptoms, hence the need to get more sensitive and accurate testing offered by our clinic (insert link here).

The common signs and symptoms of hypothyroidism

Hypothyroidism affects all organ systems, which means it presents with diverse symptomatology.

  • Feeling tired all the time

  • Dry hair and skin

  • Hypersomnia (i.e., sleeping long hours)

  • Muscular atrophy

  • Cold extremities

  • Mood swings and depression

  • Bulged eyes

  • Hoarseness

  • Constipation

  • Brittle hair

  • Decreased libido

  • Myalgia and arthralgia

  • Peripheral edema (swelling)

  • Unexplained weight gain

  • Carpel Tunnel Syndrome

  • Irregular menses

  • Heart palpitations

Thyroid testing

To comprehensively address thyroid hormone issues, one must conduct sensitive and specific testing of thyroid hormones, followed by an appropriate treatment plan.

For instance, a full thyroid panel must test for: TSH, fT4, fT3, rT3, Anti-TPO ab., Anti-TG ab., and SHBG.

Note that thyroid hormone production is intertwined with several other functions, including inflammation, methylation, nutritional status, toxins in the blood, and the presence of cardiovascular risk factors, which may require further testing.

Checking the function of the adrenal glands (e.g., cortisol production) is not always indicated, but it will be decided on a case-to-case basis.

Other complementary tests may also include checking for oestrogen, progesterone, testosterone, full blood sugar panel, and food intolerances.

To learn more about possible thyroid affects on your current health symptoms, book in your initial consultation to get the answers and support you need.

In good health,

Suzzi Hartery

BHSc Naturopath (Distinction) The Feel Good Society Founder & Head Practitioner


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